Specification :

Streptozocin CAS: 18883-66-4 98.5% -101.5%
STZ, streptozotocin
Molecular formula: C8H15N3O7 Molecular Weight: 265.22
Description: This product nitrosourea class of antibiotics, mainly used for islet cell carcinoma ( B cells or B-cell cancer) , the carcinoid tumor, Hodgkin' s disease, colon andliver cancer and other changes have some effect. Commonly used in diabetes laboratorymodel of replication.
Pharmacological effects:
Stre.achromogenes Uar.128 nitrosourea produced antibiotics, with different fat-soluble nitrosourea, is that in a methyl ethyl chloride, the other end of themolecule is an amino sugar. STZ can be self-decomposition lively methyl carbon ions, and DNA was cross-linked chains, so that the DNA alkylation, but its effects than otheralkylating nitrosourea drugs is weak, and its metabolites methylethylidene urea nitratealkylation STZ stronger than its 3 to 4 times. STZ in vivo formation of isocyanates. Protein binding to nucleic acids and inhibit DNA polymerase activity, so difficult to repairdamaged DNA. During the course of the study found that anti-tumor, STZ rats canincrease blood sugar in dogs and monkeys can cause diabetes, and was permanent. The role of diabetes with STZ species differences, in the guinea pig does not cause, nor causethe people. The mechanism of induced diabetes in islet cells was mainly due tonicotinamide adenine ( DNA) content decreased, STZ glucose-based molecules can enter the ² -cell STZ, causing morphological changes of the nucleus ² , to chromosome condensation, elongation, and concentrated .
Physical Properties: Light yellow crystalline powder, melting point 115C ( decomposition) .This product is soluble in water, but its solution is very unstable at room temperature, can be broken down in half an hour after the gas and evaporate, so the need now with the existing. Lower degree of alcohol and ketone soluble and insoluble in polar organicsolvents.