Specification :

CAS: 366-70-1
Calculated by the dry basisContent C12H19N3O.HCl More 98.0
Apperance:White crystal power
This product is soluble in water, slightly soluble in ethanol, almost insoluble in ether
Melting point:218 ^226 C
Take the goods 1.0g, plus 100ml of water allows the dissolved,
according to the determination, pH value of 3.0 ~ 4.0.
Loss on drying:Less 1.0%
Identification (1) get the goods about 10mg, dissolved by adding water, sodium carbonate test solution add 1ml test solution with a few drops of potassium permanganate, after rocking, that is, the disappearance of the color of potassium permanganate.
(2) take the goods, additional hydrochloric acid (9 ’ 1000) made about each 1ml of the solution containing 10¼g, as spectrophotometry (Appendix c A) measured at 232nm wavelength of maximum absorption, the absorption of about 0.49.
(3) the goods marked chloride aqueous solution of the differential response (Appendix b).
Determination of the goods from about 0.25g, said precision set, add 50ml of water dissolved nitrate plus 3ml, precision liquid plus silver nitrate titration (0.1mol / L) 20ml, dibutyl phthalate plus about 3ml, strong After rocking, plus instructions ammonium ferric sulfate solution 2ml, titration with ammonium thiocyanate solution (0.1mol / L) titration, and the results of titration experiments with blank correction. 1ml of each titration with silver nitrate solution (0.1mol / L) is equivalent to 25.78mg of C12H19N3O.HCl.
Type:Anti Cancer Drug
Usage & Application:
This product has a cytotoxic role in vivo release of DNA methylation and the combination of positive ions to depolymerization.
Clinical for the treatment of Hodgkin's disease, malignant lymphoma, myeloma, melanoma, brain tumors, lung cancer.
Dosage & how to take:
Oral, from the daily 50mg ~ 100mg / m 2 starting after 1 week increasing to daily 150mg ~ 200mg / m 2, the general sub-3 suits, once a 2 to 3 weeks, and then two weeks and then stop, or a daily maintenance dose 100mg / m 2, appeared to drug toxicity.
Side effects:
1 common gastrointestinal reactions are nausea, vomiting, occasional stomatitis, dry mouth, difficulty swallowing, diarrhea and constipation.
2 can induce bone marrow suppression of white blood cells, thrombocytopenia, bleeding tendency can also be caused by anemia. ,
3 more common headache, fatigue, drowsiness, occasional dizziness, depression, insomnia, hallucinations, ataxia, diplopia and nystagmus. Also shows that muscle pain and joint pain and so on. Rare coma and convulsions.
4 occasional atopic dermatitis, herpes, prurigo, such as pigmentation and hair loss.
5 other symptoms of shivering, fever and sweating, tachycardia and blood pressure dropped occasionally.
6, liver, kidney dysfunction or reduction are used with caution. Pregnant women should not be applied