Specification :

Gadoteric acid Gd-DOTA (CAS: 122795-43-1)
CAS Number: 72573-82-1
English synonyms: Gadoteric acid; Gadoteric; Gadolinium 2 - [4,7,10-tris (carboxymethyl) -1,4,7,10-tetraazacyclododec-1-yl] acetic acid
English synonyms: Gd Special acid; 2 - [4,7,10 - Tris (carboxymethyl) -1,4,7,10 - Central tetraazamacrocycle 12 -1 - yl] acetic acid gadolinium
CBNumber: CB31117315
Molecular formula: C16H25GdN4O8

Types :cardiac drugs
Apprance: colorless liquid
This product is pharmaco phosphodiesterase inhibitor, amrinone for similar drugs, the mechanism of the same with amrinone. Oral and intravenous administration were effective, the role of both positive inotropic and vasodilator effect. But the role of amrinone than strong 10 to 30 times. Better tolerance. This product is positive inotropic effect mainly through phosphodiesterase inhibition, so that cells in the inner myocardial adenosine triphosphate (CAMP) concentration increased, an increase of intracellular calcium, to enhance myocardial contractility, increased cardiac output. With epinephrine? 1 receptor, or cardiac myocyte Na +, K +-ATP enzyme has nothing to do. The role of its vasodilator effect may be direct or due to the small arteries, which can reduce the heart before and after the load, reducing left ventricular filling pressure and improve left ventricular function, increased cardiac index, but mean arterial pressure and heart rate had no significant effect. Milrinone cardiovascular effect and dose-related, mainly the performance of low-dose positive inotropic effect is, when the dose increased gradually to reach the maximum steady-state positive inotropic effect, its role in the expansion of blood vessels can also be with the dose of increase gradually strengthen. This product is on the block with the safety of patients. This product, when adverse reactions oral heavier, not long-term application.
Pharmacokinetics:intravenous administration of 5 ~ 15 minutes to take effect, clear the half-life of 2 ~ 3 hours. Protein binding rate of 70%.
Indication :apply to digitalis, diuretics, vasodilator therapy is ineffective or causes of a variety of acute and chronic refractory congestive heart failure.
Dosage intravenous use: load 25 ~ 75ug / �, 5 ~ 10 minutes slow intravenous injection, every minute after 0.25 ~ 1.0ug / kg to maintain. Maximum daily dose does not exceed 1.13mg / kg. Oral: A 2.5 ~ 7.5mg, daily 4 times.