Specification :

Nicosulfuron

Common name: nicosulfuron
IUPAC name: 2-( 4, 6-dimethoxypyrimidin-2-ylcarbamoylsulfamoyl) -N, N-dimethylnicotinamide; 1-( 4, 6-dimethoxypyrimidin-2-yl) -3-( 3-dimethylcarbamoyl-2-pyridylsulfonyl) ure a
Chemical Abstracts name: 2-[ [ [ [ ( 4, 6-dimethoxy-2-pyrimidinyl) amino] carbonyl] amino] sulfonyl] -N, N-dimeth yl-3-pyridinecarboxamide
CAS RN: [ 111991-09-4]

PHYSICAL CHEMISTRY
Mol. wt.: 410.4; M.f.: C15H18N6O6S; Form: Colourless crystals. M.p.: 169-172 ° C; V.p.: 2000 mg/ kg. Moderate eye irritant; not a skin irritant ( rabbits) ; not a skin sensitiser ( guinea pigs) . The 75% formulation is not an eye irritant.
Inhalation: LC50 for rats ( 4 h) 5.47 mg/ l.
NOEL: In 28 d feeding trials on rats and mice, no adverse effect up to 30 g/ kg diet.
Other: Non-mutagenic in the Ames test.
Toxicity class: WHO ( a.i.) III ( Table 5) ; EPA ( formulation) IV

ECOTOXICOLOGY
Birds: Dietary oral LD50 for bobwhite quail > 2250 mg/ kg. Dietary LC50 for mallard ducks and bobwhite quail > 5620 ppm.
Fish: LC50 ( 96 h) for bluegill sunfish and rainbow trout > 1000 mg/ l.
Daphnia: LC50 ( 48 h) > 1000 mg/ l.
Algae: NOEC ( 96 h) for green algae 100 mg/ l.
Bees: LD50 ( contact) > 20 ug/ bee; dietary LC50 ( 48 h) > 1000 ppm. NOEC 500 ppm.
Worms: LC50 ( 14 d) for earthworms > 1000 mg/ kg.

ENVIRONMENTAL FATE
Animals: In goats, following a dose of 60 ppm,