Butterbur Extract

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Butterbur Extract ( Petasites hybridus )
CAS: 60102-37-6 Petasites Hybridus Petasites Sesquiterpenes The Butterbur ( Petasites japonicus) has been a staple of the Japanese diet for many years and is one of the few vegetables native to Japan. Besides being recognized for its value as a staple food item it has also demonstrated anti-allergenic properties in recent studies and clinical trials. The Butterbur plant contains flavor constituents, monoterpenes, sesquiterpenes and many polyphenols. The anti-allergenic properties of the aerial portion of the plant can be attributed to the eremophilane type sesquiterpenes ( of which Petasin & Iso-Petasin are major constituents) , fukinone and 2? -hydroxyfukinone. An advantage to using the aerial portion of the plant, the portion consumed as food, is that it does not contain the high levels of PA' s ( pyrrolizidine alkaloids) found in the root and rhizome. Butterbur Extract has exhibited the ability to inhibit the degranulation of mast cells, release of leukotrienes and TNF-? production all of which are associated with the inflammation and mucous secretions related to allergic rhinitis.

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