Specification :

CAS: 73590-58-6
MF: C17H19N3O3S
MW: 345.42
EINECS:
Product Categories: Drug bulk; Active Pharmaceutical Ingredients; Omeprazole; Intermediates & Fine Chemicals; Pharmaceuticals; API' s; ATPase
Mol File: 73590-58-6.mol
mp 156° C
storage temp. 2-8° C
solubility H2O: 0.5 mg/ mL
form solid
color white
Merck 6845
Stability: Stable, but hygroscopic and photosensitive. Incompatible with strong oxidizing agents. Store in the dark.
Chemical Properties White Crystalline Solid
Usage Binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative
Biological Activity H + , K + -ATPase inhibitor ( IC 50 = 5.8 ¼ M) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion ( IC 50 = 0.16 ¼ M for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacteral against Helicobacter pylori in vitro . Also inhibits CYP2C19, CYP2C9 and CYP3A ( K i values are 3.1, 40.1 and 84.4 ¼ M respectively) and blocks swelling-dependent chloride channels ( ICIswell) .
Raw materials Chloroform--> 3-Chloroperoxybenzoic acid--> o-Phenylenediamine--> 3, 5-Dimethyl-4-methoxy-2-pyridinemethanol--> Pota ssium ethylxanthate--> Benzimidazole--> 5-Methoxy-2-mercaptobenzimidazole
Packing: 1kg net/ foil bag or tin.
Delivery: Express courier.
The min. order is 10 grams.
a proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease ( PUD) , gastroesophageal reflux disease ( GORD/ GERD) , laryngopharyngeal reflux ( LPR) and Zollinger– Ellison syndrome. Omeprazole is a competitive inhibitor of the enzymes CYP2C19 and CYP2C9, and may therefore interact with drugs that depend on them for metabolism, such as diazepam, escitalopram, and warfarin; the concentrations of these drugs may increase if they are used concomitantly with omeprazole.[ 13] Clopidogrel ( Plavix) is an inactive prodrug that partially depends on CYP2C19 for conversion to its active form; inhibition of CYP2C19 blocks the activation of clopidogrel, thus reducing its effects and potentially increasing the risk of stroke or heart attack in people taking clopidogrel to prevent these events.[ 14] [ 15] Omeprazole is also a competitive inhibitor of p-glycoprotein, as are other PPIs.
We are supplying:
Prednisolone Series:
Prednisolone 50-24-8
Prednisolone Acetate 52-21-1
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Dexamethasone Series:
Dexamethasone 18296
Dexamethasone-21-Acetate 1177-87-3
Dexamethasone Sodium Phosphate 2392-39-4
Dexamethasone Palmitate 14899-36-6
Betamethasone Series:
Betamethasone 378-44-9
Betamethasone Acetate 987-24-6
Betamethasone Dipropionate 5593-20-4
Betamethasone Valerate 2152-44-5
Betamethasone Sodium Phosphate 151-73-5
Beclometasone Dipropionate 5534-09-8
Triamcinolone Series:
Triamcinolone 124-94-7
Triamcinolone Acetate
Triamcinolone Acetonide 76-25-5
Triamcinolone Acetonide 22-Acetate
Budesonide Series:
Budesonide 51333-22-3
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Muscle-relaxing Series:
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Rocuronium Bromide 119302-91-9
Methylprednisolone Series:
Methyl Prednisolone 83-43-2
Methylprednisolone Acetate 53-36-1
Methylprednisolone Sodium Succinate 2375-03-3
Others:
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Exemestane 107868-30-4
Prednisone Acetate 125-10-0
Mometasone Furoate 83919-23-7
Hydrocortisone Hemisuccinate
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Sibutramine HCL 84485-00-7
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Clomiphene Citrate 50-41-9
Clomifene 911-45-5
Modafinil 68693-11-8
Dapoxetine 119356-77-3
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Dobutramine
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