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    Supply Estradiol 50-28-2 / ycgsales2011@ gmail.com

    Price:
    negotiate
    Quantity Order:
    Payment Method:
    Telegraphic Transfer (T/T)
    Pack. & Delivery:
    pack: 1kg foil bag/ tin

    Specification :

    keyword: steroid hormones, APIs, progestogen, estrogen
    CAS: 50-28-2
    MF: C18H24O2
    MW: 272.38
    EINECS: 200-023-8
    Product Categories: Steroids; Estrogen; Hormone; Analytical Chemistry; Biochemistry; Environmental Endocrine Disruptors; Estradiol, etc. ( Environmental Endocrine Disruptors) ; Hydroxysteroids; Intracellular receptor
    Mol File: 50-28-2.mol
    mp 178-179 ° C( lit.)
    refractive index 80.4 ° ( C= 1, Dioxane)
    storage temp. 2-8° C
    form powder
    Stability: Stable. Incompatible with strong oxidizing agents.
    Hazard Codes T
    Risk Statements 60-61-45-63
    Safety Statements 53-22-36/ 37/ 39-45
    RIDADR 2811
    WGK Germany 3
    RTECS KG2975000
    HazardClass 6.1
    PackingGroup III
    Chemical Properties White Crystalline Powder
    Usage Potent mammalian estrogenic hormone produced by the ovary.
    Biological Activity Endogenous estrogen receptor ( ER) agonist ( K i values are 0.12 and 0.13 nM for ER ± and ER ² respectively) . Also high affinity ligand at membrane estrogen GPR30 receptors.
    Estradiol ( E2 or 17² -estradiol, also oestradiol) is a sex hormone. Estradiol is abbreviated E2 as it has 2 hydroxyl groups in its molecular structure. Estrone has 1 ( E1) and estriol has 3 ( E3) . Estradiol is about 10 times as potent as estrone and about 80 times as potent as estriol in its estrogenic effect. Except during the early follicular phase of the menstrual cycle, its serum levels are somewhat higher than that of estrone during the reproductive years of the human female. Thus it is the predominant estrogen during reproductive years both in terms of absolute serum levels as well as in terms of estrogenic activity. During menopause, estrone is the predominant circulating estrogen and during pregnancy estriol is the predominant circulating estrogen in terms of serum levels. Estradiol is also present in males, being produced as an active metabolic product of testosterone. The serum levels of estradiol in males ( 8-40 pg/ ml) are roughly comparable to those of postmenopausal women. Estradiol " in vivo" is interconvertible with estrone; estradiol to estrone conversion being favored. Estradiol has not only a critical impact on reproductive and sexual functioning, but also affects other organs, including the bones.
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