Celandine ( Greater) Extract

Quantity Order:

Origin:

China

Payment Method:

Telegraphic Transfer (T/T)

Quantity:

4tons/month

Pack. & Delivery:

25kg/drum or1kg/bag

Celandine ( Greater) Extract

Active Ingredient: Chelerythrine chloride
Specification: 10%
Test Method: HPLC

Celandine ( Greater) Extract Chelidonium majus L Chelerythrine chloride

Celandine ( Greater) Extract Chelidonium majus L Chelerythrine chloride
HS-No. 29392900
C21H38NO4CL ? Mr 383.8 ? CAS-No. [ 3895-92-9]
( 1, 2-Dimethoxy-N-methyl[ 1, 3] benzodioxolo[ 5, 6-c] phenanthridinium chloride) . A naturally occurring benzophenanthridine alkaloid isolated from Chelidonium majus L. Potent and cell-permeable inhibitor of protein kinase C. Induces apoptosis in HL-60 human promyelocytic leukemia cells.
Assay ( TLC) min. 95 %

Chelidonium majus ( greater celandine; in Europe tetterwort, although in America the same name refers to bloodroot) is a herbaceous perennial plant, the only species in the genus Chelidonium. It is native to Europe and western Asia and introduced widely in North America.
The lesser celandine belongs to the same order ( Ranunculales) as the greater celandine, but belongs to the buttercup family, whereas the greater celandine belongs to the poppy family.
The whole plant is toxic in moderate doses as it contains a range of isoquinoline alkaloids but there are numerous therapeutic uses when used at the correct dosage. The main alkaloid present in the herb and root is coptisine. Other alkaloids present include berberine, chelidonine, sanguinarine and chelerythrine. Sanguinarine is particularly toxic with an LD50 of only 18 mg per kg body weight. Despite this acute toxicity, sanguinarine is present in such small quantities that the LD50 dose would require > 50g of raw herb to be ingested. Caffeic acid derivatives are also present.
The effect of the fresh herb is of a mild analgesic, cholagogic, antimicrobial, oncostatic and central nervous system sedative. In animal tests, celandine is shown to be cytostatic. An immune stimulating effect has also been noted. Some studies show that the alkaloid extraction can have the same effects. The alkaloids are known to cause immobilization in mice after being taken orally or injected. The alkaloids cause limpness and tone reduction of smooth muscle in rabbits. The alkaloids are also noted to stimulate the heart and lungs of frogs, cats and dogs, raising the blood
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