camptothecine

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Name: camptothecine

Molecular formula: C20H16N2O4

Properties: light yellow needle-like crystal.

Melting pointá o 264 ~ 267 ? ? ( methanol, decomposition) .

Optical rotationá o + 31.3 ° ( chloroform: methanol 4: 1) . Noticeable in the strong blue fluorescence under ultraviolet light. Is extremely difficult to dissolve in water, slightly soluble in alcohol, chloroform and other organic solvents. Can not form a stable salt and acid.

Sourceá oSince Nyssaceae, or Apocynaceae Rubiaceae plant Camptotheca acuminata, odor false Chailong tree ( Nothapodytes foetida) , sea-surgery Ervatamia ( Ervatamia heyneana) and snakes of the alkaloids isolated from grass roots.

Effects: Clinical treatment of gastrointestinal tumors and leukemia, also has plant growth regulating activity of the role and kill insects. 10 - Hydroxy-camptothecin for the treatment of gastric cancer, liver cancer, head and neck cancer and leukemia, and fewer side effects than camptothecin lighter.

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