orlistat

Quantity Order:

Origin:

China

Pack. & Delivery:

25kg

Orlistat produced by fermentation technology Introduction

1. 1, structure, nature
Chinese name: Orlistat
English name: Orlistat
CAS No.: 96829-58-2
Molecular Formula: C29H53NO5
Molecular Weight: 495. 74
Description: white crystalline powder
Solubility: insoluble in water, soluble in methanol and ethanol, easily soluble in chloroform
Melting point: 42-46 C
Optical Rotation: -33 - -35
Purity: not less than 98%

1. 2 Overview
Orlistat ( Orlistat) is Ruishi Hao Fu Mai - Roche Co., Ltd. developed a new type of prescription weight loss drug. This product is the only fat in the diet can prevent absorption of prescription drugs, about 30% can not absorb dietary fat. Can not only help patients lose weight, but also helps to maintain body weight. This product does not act on the central nervous system, it will not affect the patients appetite. 1998, for the first time in the United States, FDA approval in 2003 for youths aged 12 to 16 obese patients.
Orlistat, mainly through inhibition of pancreatic lipase, to reduce fat absorption in the gastrointestinal tract and effect. As the body' s absorption of orlistat less than 1% , it will not cause systemic side effects. Orlistat inhibited the absorption of dietary fat will lead to the oil like it, its severity with the dietary fat content varies, this is the only side effect of orlistat. But the patients by reducing dietary fat intake Ershi reduce side effects. Therefore, the side effects of orlistat is not simply a side effect, it can help patients adjust the diet to reduce fat intake. The side effects of weight loss with orlistat is an effective sign.
Orlistat is a safe new obesity drug, it can not only reduce the patient' s weight, but also improve dyslipidemia, reduce blood pressure, improve blood sugar control and reduce cardiovascular risk factors, some of which function independently of weight loss.

2, the production process
Produced by microbial fermentation Secretary Nebo statins, and by chemical transformation, semi-synthetic orlistat. Nebo cystatin produced three factors for the contaminated bacteria Streptomyces ( Streptomyces toxytricini) , fermentation time is about 165-170 hours, the main raw material for the fermentation of glycerol, soybean meal, and linoleic acid, the fermentation process without feeding. Homogeneous of fermentation, the product is extracellular secretion, filtration mycelium, heptane solvent extraction, the product by crystallization, hydrogenation, using different solvent recrystallization three times, and improve product purity.

Process is as follows:

Three fermentation

Broth
pretreatment, plate and frame filter
Wet waste residue
flash drying
Dry waste residue
ethanol extraction
Ethanol extract
heptane extraction
Extract ( heptane phase)
evaported
Concentrate 1 ( heptane phase)
acetonitrile extraction, degreasing, washing
Extract ( acetonitrile phase)
evaported
Concentrate 2 ( acetonitrile phase)
silica gel adsorption and elution
Eluate
evaported
Concentrate 3
crystallization twice
Nebo cystatin crude
hydrogenation
Orlistat crude
cubic crystal
Wet crystal
drying
Orlistat finished

Item Specification Result
Description White to off-white powder White powder
Identification Similar to the standard Conforms
Melting point ( ) 42~ 46 Conforms
Loss on drying 0. 5% 0. 39%
Heavy metals 10ppm 5ppm
Assay 98. 0% 99. 02%
Residue on ignition 0. 1% 0. 06%
Single impurity 0. 2% 0. 08%
Total impurities 1. 0% 0. 90%

Recommend to your friends stephen@sinopharmchem.com