Specification :

Offer Sorafenib Tosylate 284461-73-0 / 4750207-59-1
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Sorafenib freebase CAS 284461-73-0
Sorafenib Tosylate CAS 4750207-59-1

Offer Sorafenib Tosylate CAS 4750207-59-1
Items Specifications Results
Appearance White to off-white solid Conforms
Identification IH-NMR
,HPLC Conforms
Melting point 225¡«235¡æ 229¡«232.5¡æ
Loss on Drying ¡Ü0.5% 0.41%
Residue on ignition ¡Ü0.2% 0.07%
Heavy metals ¡Ü20ppm Conforms
Chromatographic purity
Single impurity
Total impurity
¡Ü0.5%
¡Ü1.0%
0.21%
0.37%
Assay (anhydrous) ¡�99.0% 99.8%

Offer Sorafenib freebase CAS 284461-73-0
Product N-[4-Chloro-3-(trifluoromethyl)phenyl]-({4-[2-(N-methyl- carbamoyl)(4-
pyridyloxy)]phenyl}-amino)carboxamide (Sorafenib freebase)
CAS No [284461-73-0] Quantity 800g
MFG .Date 2008-07 Exp. Date 2010-07
Items Specifications Results
Appearance Off-white crystalline powder Conforms
Identifications 1H-NMR: Spectrum of sample corresponds to that of RS Conforms
HPLC: Retention time of sample corresponds to that of RS Conforms
Melting point 203-213¡æ 207~208¡æ
Loss on Drying NMT0.5% 0.25%
Residue on Ignition NMT0.2% 0.10%
Heavy Metal NMT 20ppm Conforms
Related Substance Individual Impurity: NMT 0.5% 0.12%
Total Impurities :NMT 1.0% 0.47%
Purity(HPLC) NLT99.0% 99.45%
Conclusion: Conform with the enterprise standard.
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