Oleanolic acid (OA)/Herbal Extract

Price:

100USD

Quantity Order:

Payment Method:

Telegraphic Transfer (T/T)

Quantity:

1000000

Pack. & Delivery:

25kgs/drum

Oleanolic acid (OA) is a triterpenoid compound that has been shown to protect against a number of hepatotoxicants, and is used in China to treat hepatitis. In the present study, we examined the effect of OA on acetaminophen (AA)-induced acute liver injury in mice and the mechanism(s) of protection. OA pretreatment (25-100 mg/kg s.c. for 3 days) remarkably decreased AA (500 mg/kg i.p.)-induced liver damage in mice, as indicated by decreased serum activities of alanine aminotransferase and sorbitol dehydrogenase, as well as by histopathological observation. Additionally, OA pretreatment mitigated AA (300-450 mg/kg i.v.)-induced depletion in liver glutathione (GSH) content. The protective effect was not evident until 24 hr after a single s.c. injection of OA (300 mg/kg) and lasted for 72 hr. To examine the mechanism of this protection, the biliary and urinary excretion of AA and AA metabolites were measured for 2 hr after AA administration (150 mg/kg i.v.) in bile duct-cannulated mice. OA pretreatment resulted in an increased urinary excretion of AA- glucuronide and a decreased biliary excretion of AA-GSH. Microsomes from OA-pretreated mice, incubated in vitro with AA, produced less benzoquinoneimine intermediate than controls, as determined by the formation of AA-GSH. Hepatic subcellular distribution of [3H] AA to the nuclear fraction was also decreased by OA. OA pretreatment of mice had no influence on liver UDP-glucuronic acid concentration, but increased hepatic glucuronosyltransferase activity toward AA.
We have a GMP certified extract factory to produce all kinds of alfalfa extract. We possess a complete set of advance equipment for extraction,refinement,column chromatoraphy,condensation and desiccation. Our quality control laboratory is well equipped with most advanced instruments,such as HPLC,UV,GC,AA etc.

Action:
1) It is used to treat hepatitis.
2) . Oleanolic acid (OA) is a triterpenoid compound that has been shown to protect against a number of hepatotoxicants

Recommend to your friends